Double Diabetes

What is Double Diabetes?

Recently a report is on rife about a study shows that more and more people are developing signs of double diabetes. Double diabetes is more complicated and difficult to handle than its both predecessors. Patient with symptoms of both type 1 and type 2 diabetes is known as patient of double diabetes.

Type 1 diabetes

Type 1 diabetes occurs when body cannot produce enough insulin. Since insulin is important protein which helps body cells to utilize glucose, lack of insulin causes high sugar level. Patient is needed to gain insulin by injection so that glucose (sugar) can be utilized properly. Some symptoms of type 1 diabetes include extreme thirst, weight loss and more frequent urination than usual. Double diabetes was usually seen in children and young adults, but now it is found in adults also.

Type 2 diabetes

A person with type 2 diabetes may feel tired all the time and lack of energy. This is because human body cells are not able to use the energy of glucose in body. This is called insulin resistance. Type 2 diabetes tends to run in families. Some of the symptoms of diabetes type 2 include urination at unusual intervals, being hungry more often, unusual lose/gain weight, frequent headaches. Diabetes type 2 if left untreated can lead to other problems of kidneys, eyes, heart, nerves and may give you a higher risk of heart attack or stroke within a year or two. Research has shown that when a person with diabetes type 1 gains weight is more likely to develop diabetes type 2. This put that pateint into the category of double diabetes.

Treating Double Diabetes

Double diabetes treatment is complicated as a patient have to deal with issues of type 1 and type 2 diabetes at the same time. Researchers believe that if weight-gain is brought under control, teatment of double diabets becomes much more easy. Until now, treatments include dietary change to one that includes less carbohydrate and more vegetables and nuts containing good fats that your body needs to be healthy.
Along with good diet a person is recommended to use medicinal treatment, insulin injection or generic pill of Glucophage diabetes medication to enable body to use insulin, is by far the best known treatment to cure diabetes type 1 and double diabetes. At this juncture, double diabetes is quiet new to medical world. Researchers assumes that double diabetes will be a great medical challenge in upcoming years, same time human body is highly vulnerable against double diabetes. Double diabetes can occur at any age, to look for signs in children and in adults.

Under Trial Chemotherapy Drug Gets Positive Response by FDA

For a targeted treatment, developed by Seattle Genetics is in trial and the company is seeking for approval with conditions. FDA has asked monitoring committee for more clinical trial data that would back the conditional approval.

FDA on Tuesday issued documents to be considered by advisory committee in the wake of company's conclusion inferred from clinical trials. No major-safety concerns were raised in documents.

The under-trial drug is brentiximab vodotin with given Adcentris as brand name. Brentiximab is indicated to treat lymphom, a type of cancer which has not responded other available treatments. The drug is believed to be effective for treatment of Hodgkin and anaplastic lymphoma by increasing effects minimizing side effects of chemotherapy. It is co-developed with japan's pharmaceutical company.

The proposed cancer treatment drug is being reviewed by cancer drugs panel of FDA. Panel also includes some non-FDA medical personnel. FDA has asked the panel to vote on whether it can approve the drug or not.

Final decision is likely to come out in August. FDA is free to take or not to take advice from the panel.

Effect of positive notion from FDA can directly be seen on stock value of the company. Shares of Seattle Genetics have risen sixty two percent in a year.

Market experts took the released documents positive as no major concerns were there which may prevent the approval. However, company woun't be able to cash in on its product if the drug is approved for Hodgkin lymphoma only.

Estimated annual sales for the drug could be between $450-$500 million.

FDA Proposes New Rule for Targeted Treatment

As per new policy, targeted therapies seeking for FDA approval would also require approval for devices the therapy is performed with.

Pharma companies are developing more targeted treatments designed according to patients' genetic structure. Manufacturers of such treatments would have to get the device reviewed if the new proposed amendment come into effect.

Before giving approval to the medicine/therapy, FDA wants to test the device used in therapies. With that being said, therapy as well as device both would require clearance certificate from FDA.

Medicines that are targeted for specific patients only, are prescribed after a diagnostic test. Efficacy of the treatment is determined by studying genetic structure of a patient. After a thorough study physicians determine whether the therapy is fit to the patient or not. Such pre-tests are known as companion diagnostics (or targeted medicines).

One such drug in review is lung cancer drug Crizotinib of Pfizer. This drug targets genetic mutaion found in non-smokers with lung cancer of type NSCLC. Pre-test for the drug has been developed by Abbott.

However, new proposed rule has two exceptional situations where a medicine and its companion test can get approval without FDA. Medicine and its diagnostic test may get auto-approval either a disease is life threatening and no other treatment is found or benefits of the treatment is far more than the risk.