GLP-1R Agonists May Help Weight Loss, New Study Reavels

University of Copenhagen scientists have come up with a study that shows Glucagon-like peptide-1 receptor (GLP-1R) agonists can be used to aid in weight loss.

The study was undertaken by university scientists in that adult participants with BODY MASS INDEX (BMI) of 25 or more and not having diabetes mellitus were examined. They were also exposed to drugs like exenatide twice in day and once in a week. Diabetes drugs such as liraglutide were also given daily at clinically applicable doses for the duration of 20 weeks. These drugs that were given to the participants come under the class of GLP-1R agonists. Oral antidiabetic drugs, placebo and insulin are given to the control group.

The study covered broad range of trials, almost 25 of them. The group which was exposed to GLP-IR agonists saw a huge contrast in their weight as compared to the control set of group. Both diabetic and non-diabetic participants showed this effect. The study came out with the conclusion that GLP-1R agonists helps towards improving diastolic, plasma collections of cholesterol, systolic blood pressure a glycaemic regulation. But does not have any effect on plasma concentrations found in liver enzymes.

Scientists also cautioned that GLP-1R agonists have some side-effects like vomiting, nausea and diarrhea. Drug did not develop hypo-glycaemia. So at last the team concluded that GLP-1R if consumed have great effect in attaining weight loss to obese patients having diabetes or not.
The study is available in BRITISH Medical Journal.

Glaucoma Treatment, Frost Predicts Huge Mart

Glaucoma is one of top causes for blindness across the world. In USA alone it is second top complication which leads to blindness. Frost & Sullivan, a market research company sees significant opportunities in pharmaceutical market of glaucoma treatment. Since glaucoma is widely occurs in old people, likelihood of market expansion is greater as patients grow old.

A rearch and analysis, titled as Analysis of the United States Glaucoma Pharmaceuticals Market, reckoned the market worth $2 billion for the year 2010. get more study details from here.

Drug treatment for glaucoma with higher efficacy, unique way to deliver drug in body and greater empasis on patient education for the disease could lead to remarkable success for the therapy. That is because around fifty percent patients are undiagnosed.

A strong need for a new drug treatment is felt for those who have glaucoma, because current therapies are inadequate and unable to meet goal.

There are couple of drug treatment for glaucoma in market such as prostaglandin and xalatan. Generic version of these drugs is likely to have negative impact on the market for participants in line to enter. Lack of innovations in treatment is believed to be because of the duration of the treatment which is usually for life time. Patients opts generics to make the treatment cost suitable to their budget.

The research is done by Frost & Sullivan.

Current eye drop treatment has not been convenient in many ways which leads to reduction in patient compliance. Difficulties in eye drops such as it cannot be self administered, greater frequency i.e. three times a day and failure to meet prescription duration mostly ends up discontinuation of treatment.

Erectile Dysfunction Drugs Safer for Diabetics- Says Report

Erectile dysfunction is a problem that has devastated the conditions of many. The disease is such that there are drugs to fight it (viagra, cialis or Kamagra), but these drugs end up leaving several side effects in the body. There are mild speculations that do the round that erectile dysfunction drugs have ill effects on patients with diabetics. However, a recent study has shown that ED drugs are safe for diabetic patients. This study has been really beneficial for several people with diabetics and for doctors who have been reluctant to prescribe diabetes medicines to patients.

Dr Moshe Vardi, M.D., with the internal medicine division at Lady Davis Carmel Medical Center in Israel said that observation has not come as surprise to them but provides support to the notion that this class of drug is efficient and secure for a specific class of people. The medications that are available are considered the basis of treatment for erectile dysfunction for the general populace. However, patients with diabetes are more likely to variations in the results of these drugs as they have various complications and the process of their erectile dysfunction are multifactorial, thus making their treatment a almost a challenge for physicians and health care professionals.

An international organization called The Cochrane Collaboration conducted a research that included the around 1,700 men who had diabetes. The men varied in age, ethnicity and weight. After the 12 week study it was found that about 30 percent of men were reported with massive improvement in their sex life and no reported were found that had any type of complications related to diabetes.

Double Diabetes

What is Double Diabetes?

Recently a report is on rife about a study shows that more and more people are developing signs of double diabetes. Double diabetes is more complicated and difficult to handle than its both predecessors. Patient with symptoms of both type 1 and type 2 diabetes is known as patient of double diabetes.

Type 1 diabetes

Type 1 diabetes occurs when body cannot produce enough insulin. Since insulin is important protein which helps body cells to utilize glucose, lack of insulin causes high sugar level. Patient is needed to gain insulin by injection so that glucose (sugar) can be utilized properly. Some symptoms of type 1 diabetes include extreme thirst, weight loss and more frequent urination than usual. Double diabetes was usually seen in children and young adults, but now it is found in adults also.

Type 2 diabetes

A person with type 2 diabetes may feel tired all the time and lack of energy. This is because human body cells are not able to use the energy of glucose in body. This is called insulin resistance. Type 2 diabetes tends to run in families. Some of the symptoms of diabetes type 2 include urination at unusual intervals, being hungry more often, unusual lose/gain weight, frequent headaches. Diabetes type 2 if left untreated can lead to other problems of kidneys, eyes, heart, nerves and may give you a higher risk of heart attack or stroke within a year or two. Research has shown that when a person with diabetes type 1 gains weight is more likely to develop diabetes type 2. This put that pateint into the category of double diabetes.

Treating Double Diabetes

Double diabetes treatment is complicated as a patient have to deal with issues of type 1 and type 2 diabetes at the same time. Researchers believe that if weight-gain is brought under control, teatment of double diabets becomes much more easy. Until now, treatments include dietary change to one that includes less carbohydrate and more vegetables and nuts containing good fats that your body needs to be healthy.
Along with good diet a person is recommended to use medicinal treatment, insulin injection or generic pill of Glucophage diabetes medication to enable body to use insulin, is by far the best known treatment to cure diabetes type 1 and double diabetes. At this juncture, double diabetes is quiet new to medical world. Researchers assumes that double diabetes will be a great medical challenge in upcoming years, same time human body is highly vulnerable against double diabetes. Double diabetes can occur at any age, to look for signs in children and in adults.

Insulin: FAQ for Diabetes Patients

What is Insulin?
Insulin is essential body hormone produced by pancreas gland. Glucose is made from the eaten food. This glucose is essential for cells to generate energy. However, absorption depends on insulin. Higher level of glucose in blood is known as diabetes. There are two types of diabetes; Type 1 diabetes and Type 2 diabetes. Diabetes is known as Type 1 when pancreas gland does not produce enough insulin. Diabetes is known as Type 2 when produced insulin does not work properly.

How do we get Insulin?
In early time, because of lack of technology, insulin was procured from pancreas glands on dead animal. Today, with the help of advanced technology, insulin is being prepared in laboratory. Advantage of using insulin prepared in laboratory is it is not contaminated. There are three types of insulin beef insulin, pork insulin, man insulin (name pattern is because of resembling structure insulin).

Who with Diabetes needs Insulin?
Being unable to produce insulin in type 1 diabetes, patients must be given from externally. For patients with Type 2 diabetes, there are many diabetes drugs in market. Avandia and Actos are some of them. It is advisable for type 2 diabetes patient to control blood glucose level with suggested diet along with medicine.

What is the best treatment for Type 2 Diabetes?
There are two options for type 2 diabetes patients. One, take diabetes drugs such as actos and Avandia; Two, have insulin externally. Both the option, however, must be accompanied by strict diet suggested by doctor.

Most of the Diabetes patients avoid painful injection of insulin and prefer diabetes drugs along with proper diet.

[Note: There are drugs under trial that requires to be taken once a week and once a month]

Diabetes drug works either by improving insulin production or by increasing insulin sensitivity. Scientists know how what is going wrong, but they don’t know why it is going wrong. In other words, health experts know that pancreas gland is malfunctioning (producing lesser insulin) but they do not know the causes.

Diabetes Cure with Cinnamon Abstract

Cinnamon extract can help reduce risk factors that may lead to diabetes and heart diseases. An antioxidative compounds found in cinnamon were found to cut the factors that eventually leads to some chronic diseases.
Richard Anderson conducted a study of 22 obese patients. These patients are likely to develop diabetes because of impaired glucose level in their blood. Richard Anderson, a chemist at USDA, along with Tim Zeigenfuss studied blood samples of participants.

It was made sure that participants are in prediabetes stage. Patients who are diagnosed with prediabetes are those who have insulin resistant level higher than the normal. Insulin is produced by pancreas and used by cells for better consumption of glucose in blood. Insulin resistance of cells increases blood glucose level.


Participants were divided into two groups. One group of participants was given 250mgs of water soluble cinnamon extract two times a day and another group was administered with placebo. Inspection of blood was done thrice during the entire study.

Study revealed that dried water soluble cinnamon extract increased antioxidant compounds by 12%-24%. Furthermore, level of level of glucose found correlated to increased level of antioxidant compound.

More detail research is needed to confirm the findings of study.

Journal of the American College of Nutrition.